![]() ![]() Since sodium thiosulfate (STS) is both an effective cyanide antidote and neutralizing agent capable of binding to reactive chemicals or metabolites, its antidotal role was investigated in mice exposed to 60 mg/kg intraperitoneal (IP) ACN injection. Many have suggested that ACN or its reactive metabolite acts directly at the target tissues, while others have implicated the release of CN ions from the parent compound as the toxic moiety. Sodium thiosulfate Mechanism of actionĪlthough acute acrylonitrile (ACN) toxicity is very profound, the mechanism of its toxicity and immediate lethality is unclear. Evidence-based medicine for Chemical Defense - including efficacy and safety A. ![]() ![]() Sodium thiosulfate can be used for treatment of acute cyanide poisoning in combination with sodium nitrite. Chemical Defense therapeutic area(s) - including key possible uses Name of Chemical Defense therapeutic agent/device ![]()
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